selected items:
Vladimirov N, Voigt FF, Naert T, Araujo GR, Cai R, Reuss AM, Zhao S, Schmid P, Hildebrand S, Schaettin M, Groos D, Mateos JM, Bethge P, Yamamoto T, Aerne V, Roebroeck A, Ertürk A, Aguzzi A, Ziegler U, Stoeckli E, Baudis L, Lienkamp SS, Helmchen F. Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples. Nat Commun. 2024 Mar 27;15(1):2679. doi: 10.1038/s41467-024-46770-2.
Tröndle, K., Rizzo, L., Pichler, R., Zimmermann, S., & Lienkamp, SS. (2024). Flow induces common and specific transcriptional changes in renal tubular epithelial cells involving the PI3K pathway. (2024) The FASEB Journal, 38(1), e23329. https://doi.org/10.1096/fj.202300834R
Voigt, F. F., Reuss, A. M., Naert, T., Hildebrand, S., Schaettin, M., Hotz, A. L., Whitehead, L., Bahl, A., Neuhauss, S. C. F., Roebroeck, A., Stoeckli, E. T., Lienkamp, S. S., Aguzzi, A., & Helmchen, F. (2023). Reflective multi-immersion microscope objectives inspired by the Schmidt telescope. Nature Biotechnology Mar 30. https://doi.org/10.1038/s41587-023-01717-8.
Grand, K., Stoltz, M., Rizzo, L., Röck, R., Kaminski, M., Salinas, G., Getwan, M., Naert, T., Pichler, R., & Lienkamp, SS. (2023). HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes. Journal of the American Society of Nephrology: JASN, Mar 1;34(3):412-432. https://doi.org/10.1038/s41587-023-01717-8.
Pichler, R., Rizzo, L., Tröndle, K., Bühler, M., Brucker, H., Müller, A.-L., Grand, K., Farè, S., Viau, A., Kaminski, M. M., Kuehn, E. W., Koch, F., Zimmermann, S., Koltay, P., & Lienkamp, SS. (2022). Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease. Biomaterials, 291, 121910. https://doi.org/10.1016/j.biomaterials.2022.121910
Naert, T., Çiçek, Ö., Ogar, P., Bürgi, M., Shaidani, N.-I., Kaminski, M. M., Xu, Y., Grand, K., Vujanovic, M., Prata, D., Hildebrandt, F., Brox, T., Ronneberger, O., Voigt, F. F., Helmchen, F., Loffing, J., Horb, M. E., Willsey, H. R., Lienkamp, S. S. (2021). Deep learning is widely applicable to phenotyping embryonic development and disease. Development (Cambridge, England), 148(21), dev199664. https://doi.org/10.1242/dev.199664 (cover article)
see accompanying materials and resources page for pre-trained models and instructional videos
Getwan M, Hoppmann A, Schlosser P, Grand K, Song W, Diehl R, Schroda S, Heeg F, Deutsch F, Hildebrandt F, Lausch E, Köttgen A, Lienkamp SS. (2021) Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease. Proceedings of the National Academy of Sciences of the United States of America, Sep 28;118(39):e2106770118. doi: 10.1073/pnas.2106770118. (direct submission, cover article)
Knoche BB, Busche C, Grodd M, Busch H-J, Lienkamp SS. A simulation-based pilot study of crisis checklists in the emergency department. (2021) Intern Emerg Med. Published online March 9, 2021. doi:10.1007/s11739-021-02670-7
Hoff S, Epting D, Falk N, Schroda S, Braun AD, Halbritter J, Hildebrandt F, Kramer-Zucker A, Bergmann C, Walz G, Lienkamp SS. (2018) The nucleoside diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development. Journal of Biological Chemistry Sep 28;293(39)
Lagies S, Pichler R, Kaminski MM, Schlimpert M, Walz G, Lienkamp SS, and Kammerer B. (2018) Metabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs). Scientific reports 8, 3878.
Kaminski M, Tosic J, Kresbach C, Engel H, Klockenbusche J, Müller A-L, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS. (2016) Direct Reprogramming of Fibroblasts into Renal Tubular Epithelial Cells by Defined Transcription Factors. Nature Cell Biology 18, 1269-1280.
Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstadter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, and Lienkamp SS. (2013) ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nature genetics 45, 951-956.
Lienkamp SS, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB**, and Walz G**. (2012) Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension. Nature genetics 44, 1382-1387.
Lienkamp S, Ganner A, Boehlke C, Schmidt T, Arnold SJ, Schafer T, Romaker D, Schuler J, Hoff S, Powelske C, Eifler A, Kronig C, Bullerkotte A, Nitschke R, Kuehn EW, Kim E, Burkhardt H, Brox T, Ronneberger O, Gloy J, and Walz G. (2010) Inversin relays Frizzled-8 signals to promote proximal pronephros development. Proceedings of the National Academy of Sciences of the United States of America 107, 20388-20393. (direct submission)
For full list see pubmed.